The platelet‑derived growth factor (PDFG) signaling pathway exerts persistent activation in
response to a variety of stimuli and facilitates the progression of hepatic fibrosis. Since this …

Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis and inflammation
and, in some patients, progressive fibrosis leading to cirrhosis. An understanding of the …

Objectives Evidences demonstrate that sorafenib alleviates liver fibrosis via inhibiting HSC
activation and ECM accumulation. The underlying mechanism remains unclear. Ferroptosis …

Ferroptosis is a recently recognized form of regulated cell death that is characterized by lipid
peroxidation. However, the molecular mechanisms regulating ferroptosis are largely …

Proliferating hepatic stellate cells (HSC s) respond to liver damage by secreting collagens
that form fibrous scar tissue, which can lead to cirrhosis if in appropriately regulated …

Janus protein tyrosine kinase (JAK) has the ability to activate signal transducer and activator
of transcription (STAT). STAT3 is a valued member of the JAK/STAT signaling pathway. In …

Liver fibrosis leads to liver cirrhosis and failure, and no effective treatment is currently
available. Growing evidence supports a link between mitochondrial dysfunction and liver …

The morbidity and mortality of hepatic fibrosis caused by various etiologies are high
worldwide, and the trend is increasing annually. At present, there is no effective method to …

Objective Liver fibrosis constitutes a major health problem worldwide due to its rapidly
increasing prevalence and the lack of specific and effective treatments. Growing evidence …

The low grade inflammatory state present in obesity promotes the progression of Non-
Alcoholic Fatty Liver Disease (NAFLD). In Non-Alcoholic Steatohepatitis (NASH) …