Molecularly targeted agents promise to revolutionize therapeutics by reducing morbidity and
mortality in patients with cancer. However, despite an urgent need for more effective …

Mouse models of cancer have proven to be an indispensable resource in furthering both our
basic knowledge of cancer biology and the translation of new cancer treatments and …

Here, we establish a CT-radiomics based method for application in invasive, orthotopic
rodent brain tumour models. Twenty four NOD/SCID mice were implanted with U87R-Luc2 …

Development of the novel diagnostic and therapeutic approaches in neuro-oncology
requires tumor models that closely reproduce the biological features of patients' tumors …

Pancreatic cancer is the third most common cancer diagnosed in the United States, with
more than 53,000 new cases in 2017. It is the fourth leading cause of cancer-related death …

Background: Glioblastoma (GBM), being a highly vascularised and locally invasive tumour,
is an attractive target for anti-angiogenic and anti-invasive therapies. The GBM/endothelial …

Background: Resistance to temozolomide (TMZ) greatly limits chemotherapeutic
effectiveness in glioblastoma (GBM). Here we analysed the ability of the Inhibitor-of …

Background: Glioblastoma is characterised by extensive infiltration into the brain
parenchyma, leading to inevitable tumor recurrence and therapeutic failure. Future …

Objective: Clinically relevant animal models of non-small cell lung carcinoma (NSCLC) are
required for the validation of novel treatments. We compared two different orthotopic …

Purpose Preclinical models of epithelial ovarian cancer have not been exploited to evaluate
the clinical standard combination therapy of surgical debulking with follow-up …