Neurodegenerative diseases are incurable debilitating disorders characterized by structural
and functional neuronal loss. Approximately 30 million people are affected worldwide, and …

Hemoglobins (Hbs) are heme-containing proteins binding oxygen, carbon monoxide, and
nitric oxide. While erythrocytes are the most well-known location of Hbs, Hbs also exist in …

Serpins represent the most broadly distributed superfamily of proteases inhibitors. They
contribute to a variety of physiological functions and any alteration of the serpin-protease …

Opioid use disorder (OUD) is influenced by genetic and environmental factors. While recent
research suggests epigenetic disturbances in OUD, this is mostly limited to DNA methylation …

Objective Progressive supranuclear palsy (PSP) is a 4R‐tauopathy showing heterogeneous
tau cytopathology commencing in the globus pallidus (GP) and the substantia nigra (SN) …

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the
substantia nigra and localized deposition of cytoplasmic fibrillary inclusions as Lewy bodies …

Piwi interacting RNAs (piRNAs) are small non-coding single-stranded RNA species 20–31
nucleotides in size generated from distinct loci. In germline tissues, piRNAs are amplified via …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect
of cancer treatment, often associated with degeneration of sensory axons or their terminal …

Pantothenate kinase (PanK) is the first enzyme in the coenzyme A (CoA) biosynthetic
pathway. The differential expression of the four-active mammalian PanK isoforms regulates …

Iron is essential for brain development and health where its redox properties are used for a
number of neurological processes. However, iron is also a major driver of oxidative stress if …