To understand the placement of a certain protein in a physiological system and the
pathogenesis of related disorders, it is not only of interest to determine its function but also …

Conventional de novo drug design is time consuming, laborious, and resource intensive. In
recent years, emerging in silico approaches have been proven to be critical to accelerate the …

Thiol groups can undergo numerous modifications, making cysteine a unique molecular
switch. Cysteine plays structural and regulatory roles as part of proteins or glutathione …

Von Willebrand disease (VWD) is a bleeding disorder that is mainly caused by mutations in
the multimeric protein von Willebrand factor (VWF). These mutations may lead to …

Megakaryocyte-derived platelets and endothelial cells store their hemostatic cargo in α-and
δ-granules and Weibel-Palade bodies, respectively. These storage granules belong to the …

Patients with von Willebrand disease (VWD) are often heterozygous for a missense mutation
in the von Willebrand factor (VWF) gene. Investigating the pathogenic features of VWF …

Summary Weibel–Palade bodies (WPBs) are the storage organelles for von Willebrand
factor (VWF) in endothelial cells. VWF forms multimers that assemble into tubular structures …

Multimeric von Willebrand factor (VWF) is essential for primary hemostasis. The biosynthesis
of VWF high-molecular-weight multimers requires spatial separation of each step because of …

The NADPH oxidase (NOX) complex has been shown to play a crucial role in stress
response and in the virulence of various fungal pathogens. The underlying molecular …

Disulfide Bonds in Protein Folding and Stability | Oxidative Folding of Proteins: Basic
Principles, Cellular Regulation and Engineering | Books Gateway | Royal Society of Chemistry …