Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …

Epigenetics has enriched human disease studies by adding new interpretations to disease
features that cannot be explained by genetic and environmental factors. However …

Background Recent interest in reference-free deconvolution of DNA methylation data has
led to several supervised methods, but these methods do not easily permit the interpretation …

Background Variation in cancer risk among somatic tissues has been attributed to variations
in the underlying rate of stem cell division. For a given tissue type, variable cancer risk …

Identifying molecular alterations in normal tissue adjacent to cancer is important for
understanding cancer aetiology and designing preventive measures. Here we analyse the …

The incidence of type 1 diabetes (T1D) has substantially increased over the past decade,
suggesting a role for non-genetic factors such as epigenetic mechanisms in disease …

Single-cell omics is transforming our understanding of cell biology and disease, yet the
systems-level analysis and interpretation of single-cell data faces many challenges. In this …

Background A healthy immune system requires immune cells that adapt rapidly to
environmental challenges. This phenotypic plasticity can be mediated by transcriptional and …

It is well-established that the DNA methylation landscape of normal cells undergoes a
gradual modification with age, termed as 'epigenetic drift'. Here, we review the current state …

In ''Omics''era of the life sciences, data is presented in many forms, which represent the
information at various levels of biological systems, including data about genome …