Deciphering the principles and mechanisms by which gene activity orchestrates complex
cellular arrangements in multicellular organisms has far-reaching implications for research …

The development of high-throughput RNA sequencing (RNA-seq) at the single-cell level has
already led to profound new discoveries in biology, ranging from the identification of novel …

Technological advances have made it possible to measure spatially resolved gene
expression at high throughput. However, methods to analyze these data are not established …

Understanding cell type identity in a multicellular organism requires the integration of gene
expression profiles from individual cells with their spatial location in a particular tissue …

A major challenge in developmental biology is to understand the genetic and cellular
processes/programs driving organ formation and differentiation of the diverse cell types that …

Advances in multiplexed in situ imaging are revealing important insights in spatial biology.
However, cell type identification remains a major challenge in imaging analysis, with most …

The emerging single-cell RNA-Seq (scRNA-Seq) technology holds the promise to
revolutionize our understanding of diseases and associated biological processes at an …

Statistical methods in integrative genomics aim to answer important biology questions by
jointly analyzing multiple types of genomic data (vertical integration) or aggregating the …

Pericryptal myofibroblasts in the colon and rectum play an important role in regulating the
normal colorectal stem cell niche and facilitating tumor progression. Myofibroblasts …

Neurosecretory centers in animal brains use peptidergic signaling to influence physiology
and behavior. Understanding neurosecretory center function requires mapping cell types …