EndoPRS: Incorporating Endophenotype Information to Improve Polygenic Risk Scores for Clinical Endpoints

EV Kharitonova, Q Sun, F Ockerman, B Chen, LY Zhou… - medRxiv, 2024 - medrxiv.org
Polygenic risk score (PRS) prediction of complex diseases can be improved by leveraging
related phenotypes. This has motivated the development of several multi-trait PRS methods …