Mass spectrometry-based techniques to elucidate the sugar code
Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …
and glycans. Although glycans are essential to all living organisms, surprisingly little is …
Sweet but Challenging: Tackling the Complexity of GAGs with Engineered Tailor‐Made Biomaterials
J Le Pennec, C Picart, RR Vivès… - Advanced …, 2024 - Wiley Online Library
Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …
Analysis of the glycosaminoglycan chains of proteoglycans
Glycosaminoglycans (GAGs) are heterogeneous, negatively charged, macromolecules that
are found in animal tissues. Based on the form of component sugar, GAGs have been …
are found in animal tissues. Based on the form of component sugar, GAGs have been …
Developments in mass spectrometry for glycosaminoglycan analysis: a review
This review covers recent developments in glycosaminoglycan (GAG) analysis via mass
spectrometry (MS). GAGs participate in a variety of biological functions, including cellular …
spectrometry (MS). GAGs participate in a variety of biological functions, including cellular …
Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides
RL Miller, SE Guimond, R Schwörer… - Nature …, 2020 - nature.com
Despite evident regulatory roles of heparan sulfate (HS) saccharides in numerous biological
processes, definitive information on the bioactive sequences of these polymers is lacking …
processes, definitive information on the bioactive sequences of these polymers is lacking …
Characterization and quantification of highly sulfated glycosaminoglycan isomers by gated-trapped ion mobility spectrometry negative electron transfer dissociation …
Glycosaminoglycans (GAGs) play vital roles in many biological processes and are naturally
present as complex mixtures of polysaccharides with tremendous structural heterogeneity …
present as complex mixtures of polysaccharides with tremendous structural heterogeneity …
State‐of‐the‐art glycosaminoglycan characterization
A Zappe, RL Miller, WB Struwe… - Mass Spectrometry …, 2022 - Wiley Online Library
Glycosaminoglycans (GAGs) are heterogeneous acidic polysaccharides involved in a range
of biological functions. They have a significant influence on the regulation of cellular …
of biological functions. They have a significant influence on the regulation of cellular …
Recent liquid chromatographic approaches and developments for the separation and purification of carbohydrates
Carbohydrate purification remains a bottleneck in securing analytical standards from natural
sources or by chemical or enzymatic synthesis. This review highlights the scope and …
sources or by chemical or enzymatic synthesis. This review highlights the scope and …
Resolving heparan sulfate oligosaccharide positional isomers using hydrophilic interaction liquid chromatography-cyclic ion mobility mass spectrometry
GJ Cavallero, J Zaia - Analytical chemistry, 2022 - ACS Publications
Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell
surfaces and within extracellular matrices in all animal tissues. Many biological processes …
surfaces and within extracellular matrices in all animal tissues. Many biological processes …
Characterization of an α-agarase from Thalassomonas sp. LD5 and its hydrolysate
W Zhang, J Xu, D Liu, H Liu, X Lu, W Yu - Applied microbiology and …, 2018 - Springer
It has been a long time since the first α-agarase was discovered. However, only two α-
agarases have been cloned and partially characterized so far and the study of α-agarases …
agarases have been cloned and partially characterized so far and the study of α-agarases …