Stimuli-responsive therapeutic metallodrugs

X Wang, X Wang, S Jin, N Muhammad, Z Guo - Chemical reviews, 2018 - ACS Publications
The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …

Molecular photosensitisers for two-photon photodynamic therapy

F Bolze, S Jenni, A Sour, V Heitz - Chemical Communications, 2017 - pubs.rsc.org
Two-photon excitation has attracted the attention of biologists, especially after the
development of two-photon excited microscopy in the nineties. Since then, new applications …

Combination of Ru (II) complexes and light: new frontiers in cancer therapy

C Mari, V Pierroz, S Ferrari, G Gasser - Chemical science, 2015 - pubs.rsc.org
The synergistic action of light, oxygen and a photosensitizer (PS) has found applications for
decades in medicine under the name of photodynamic therapy (PDT) for the treatment of …

Fighting cancer with corroles

RD Teo, JY Hwang, J Termini, Z Gross… - Chemical …, 2017 - ACS Publications
Corroles are exceptionally promising platforms for the development of agents for
simultaneous cancer-targeting imaging and therapy. Depending on the element chelated by …

Metal-containing and related polymers for biomedical applications

Y Yan, J Zhang, L Ren, C Tang - Chemical Society Reviews, 2016 - pubs.rsc.org
A survey of the most recent progress in the biomedical applications of metal-containing
polymers is given. Due to the unique optical, electrochemical, and magnetic properties, at …

Harnessing ruthenium (II) as photodynamic agents: Encouraging advances in cancer therapy

J Liu, C Zhang, TW Rees, L Ke, L Ji, H Chao - Coordination Chemistry …, 2018 - Elsevier
Despite their past triumphs, platinum-based therapeutics remain limited by chemo-
resistance and severe side effects. As an alternative therapeutic modality which bypasses …

Transition metal complexes as photosensitizers for integrated cancer theranostic applications

J Li, T Chen - Coordination Chemistry Reviews, 2020 - Elsevier
Light, oxygen and photosensitizers (PSs) are the three separate elements that have been
applied in combination in the phototherapy of cancers in the past decades. Currently …

Conjugates of porphyrinoid-based photosensitizers with cytotoxic drugs: current progress and future directions toward selective photodynamic therapy

VF Otvagin, NS Kuzmina, ES Kudriashova… - Journal of medicinal …, 2022 - ACS Publications
Photodynamic therapy (PDT) is a treatment modality where light-mediated activation of
photosensitizers in a patient's body leads to the generation of cytotoxic reactive oxygen …

Visible‐light‐induced annihilation of tumor cells with platinum–porphyrin conjugates

A Naik, R Rubbiani, G Gasser… - Angewandte Chemie, 2014 - Wiley Online Library
Despite the extensive use of porphyrins in photodynamic therapy (PDT), tetraplatinated
porphyrins have so far not been studied for their anticancer properties. Herein, we report the …

Photoactivated in vitro anticancer activity of rhenium (I) tricarbonyl complexes bearing water-soluble phosphines

SC Marker, SN MacMillan, WR Zipfel, Z Li… - Inorganic …, 2018 - ACS Publications
Fifteen water-soluble rhenium compounds of the general formula [Re (CO) 3 (NN)(PR3)]+,
where NN is a diimine ligand and PR3 is 1, 3, 5-triaza-7-phosphaadamantane (PTA), tris …