Diabetes causes metabolic and physiologic abnormalities in the retina, and these changes
suggest a role for inflammation in the development of diabetic retinopathy. These changes …

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and
one of the major causes of blindness worldwide. The pathogenesis of DR has been …

Diabetic retinopathy continues to be the leading cause of legal blindness among working-
age individuals. The earliest histological features of diabetic retinopathy include neuroretinal …

Diabetes, particularly type 2 diabetes, is a looming health issue with many ramifications.
Because diabetes alters the cellular microenvironment in many different types of tissues, it …

purpose. VEGF is a potent permeabilizing factor that contributes to the pathogenesis of
diabetic retinopathy and brain tumors. VEGF-induced vascular permeability in vivo and in …

Protein kinase C (PKC) is a family of serine/threonine protein kinases, the activation of which
plays an important role in the development of diabetic microvascular complications. The …

OBJECTIVE: To evaluate the effect of ruboxistaurin, an orally administered protein kinase C
β (PKC β) isozyme-selective inhibitor, on vision loss in patients with diabetes. DESIGN …

The purpose of this study was to evaluate the Safety and efficacy of the orally administered
protein kinase C (PKC) β isoform-selective inhibitor ruboxistaurin (RBX) in subjects with …

purpose. To determine whether celecoxib inhibits VEGF secretion from ARPE-19 cells and
to investigate further the safety and effectiveness of periocular celecoxib-poly (lactide-co …

purpose. To test whether chronic memantine (MEM) treatment improves retinal function and
prevents neurodegeneration and vascular changes in the retinas of streptozotocin (STZ) …