Resistance to therapy remains a major cause of cancer treatment failures, resulting in many
cancer-related deaths. Resistance can occur at any time during the treatment, even at the …

Schlafen (SLFN) genes belong to a vertebrate gene family encoding proteins with high
sequence homology. However, each SLFN is functionally divergent and differentially …

Proliferating cells exhibit a metabolic phenotype known as" aerobic glycolysis," which is
characterized by an elevated rate of glucose fermentation to lactate irrespective of oxygen …

Most cancers exhibit aneuploidy, but its functional significance in tumor development is
controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using …

Long non-coding RNAs (lncRNAs) act as versatile regulators of many biological processes
and play vital roles in various diseases. lncRNASNP is dedicated to providing a …

Background. Cancer is a major threat to human health worldwide. Although recent
innovations and advances in early detection and effective therapies such as targeted drugs …

Resistance to BRAF/MEK inhibitor therapy in BRAFV600‐mutated advanced melanoma
remains a major obstacle that limits patient benefit. Microenvironment components including …

Background Current immunotherapy strategies have contrasting clinical results in human
lung cancer patients as small-cell lung cancers (SCLC) often show features of …

Glioma is the most common malignant primary brain tumour. It is of great significance for the
prognosis and personalized treatment of glioma patients to accurate identification of glioma …

Two APOBEC DNA cytosine deaminase enzymes, APOBEC3A and APOBEC3B, generate
somatic mutations in cancer, thereby driving tumour development and drug resistance. Here …