The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with
interstitial fluid (ISF), may provide a clearance pathway for protein species such as amyloid …

Tissue clearing methods enable the imaging of biological specimens without sectioning.
However, reliable and scalable analysis of large imaging datasets in three dimensions …

Despite its small size, the brain consumes 25% of the body's energy, generating its own
weight in potentially toxic proteins and biological debris each year. The brain is also the only …

Whole-organ/body three-dimensional (3D) staining and imaging have been enduring
challenges in histology. By dissecting the complex physicochemical environment of the …

The brain is an energy hog, consuming available energy supplies at a rate out of all
proportion to its relatively small size. This outsized demand, largely reflecting the unique …

Various optical clearing methods have emerged as powerful tools for deep biological
imaging. Organic solvent–based clearing methods, such as three-dimensional imaging of …

The microvasculature underlies the supply networks that support neuronal activity within
heterogeneous brain regions. What are common versus heterogeneous aspects of the …

The blood-brain barrier (BBB) acts as the crucial physical filtration structure in the central
nervous system. Here, we investigate the role of a specific subset of astrocytes in the …

1300 nm three-photon calcium imaging has emerged as a useful technique to allow calcium
imaging in deep brain regions. Application to large-scale neural activity imaging entails a …

Objectives Glymphatic function has not yet been explored in behavioral variant
frontotemporal dementia (bvFTD). The spatial correlation between regional glymphatic …