The role in human health of therapeutic proteins in general, and monoclonal antibodies
(mAbs) in particular, has been significant and is continuously evolving. A considerable …

Tryptophan is one of the essential mammalian amino acids, and is thus a required
component in human nutrition, animal feeds, and cell culture media. However, this aromatic …

Many fields in chemical biology and synthetic biology require effective bioconjugation
methods to achieve their desired functions and activities. Among such biomolecule …

Large-molecule antibody biologics have revolutionized medicine owing to their superior
target specificity, pharmacokinetic and pharmacodynamic properties, safety and toxicity …

Peptide mapping is a component of the analytical toolbox used within the biopharmaceutical
industry to aid in the identity confirmation of a protein therapeutic and to monitor degradative …

The pharmaceutical industry is one of the most regulated industries worldwide, since the
drug products have to be safe and effective. The levels of impurities and degradation …

Forced degradation studies have become integral to the development of recombinant
monoclonal antibody therapeutics by serving a variety of objectives from early stage …

Highlights•Proteins undergo spontaneous degradation during manufacturing and
storage.•Chemical modifications to proteins can influence physical stability.•Predictive tools …

Ribosomally expressed proteins perform multiple, versatile, and specialized tasks
throughout Nature. In modern times, chemically modified proteins, including improved …

Peroxyl radicals participate in multiple processes involved in critical changes to cells,
tissues, pharmacueticals and foods. Some of these reactions explain their association with …