The urothelium is a stratified epithelium composed of basal cells, one or more layers of
intermediate cells, and an upper layer of differentiated umbrella cells. Most bladder cancers …

In the past decade, we have seen the emergence of sequence-based methods to
understand chromosome organization. With the confluence of in situ approaches to capture …

Simple Summary Urinary bladder cancer is one of the ten major cancers worldwide, with
higher incidences in males, in smokers, and in highly industrialized countries. New …

Muscle-invasive bladder cancer (BLCA) is an aggressive disease. Consensus BLCA
transcriptomic subtypes have been proposed, with two major Luminal and Basal subgroups …

Eukaryotic genomes are highly compacted in the cell nucleus. Two loci separated by a long
linear distance can be brought into proximity in space through DNA-binding proteins and …

Secondary trastuzumab resistance represents an evolutionary adaptation of HER2‐positive
breast cancer during anti‐HER2 treatment. Most current studies have tended to prioritize …

Advanced breast cancer (BC), especially basal like triple-negative BC (TNBC), is a highly
malignant tumor without viable treatment option, highlighting the urgent need to seek novel …

Simple Summary NPAS2, short for Neuronal PAS Domain Protein 2, is a transcription factor
involved in regulating the circadian rhythms and sleep–wake cycles in mammals, including …

NPAS2, a circadian rhythm gene encoding the neuronal PAS domain protein 2 (NPAS2),
has received widespread attention because of its complex functions in cells and diverse …

In recent years, Hi-C technology has revolutionized cancer research by elucidating the
mystery of three-dimensional chromatin organization and its role in gene regulation. This …