Quantification of endocannabinoids in biological systems by chromatography and mass spectrometry: a comprehensive review from an analytical and biological …

AA Zoerner, FM Gutzki, S Batkai, M May… - … et Biophysica Acta (BBA …, 2011 - Elsevier
The endocannabinoids anandamide (arachidonoyl ethanolamide, AEA) and 2-arachidonoyl
glycerol (2AG) are physiologically occurring, biologically active compounds on CB1 and …

[HTML][HTML] Endocannabinoids as potential biomarkers: It's all about pre-analytics

D Kratz, D Thomas, R Gurke - Journal of Mass Spectrometry and Advances …, 2021 - Elsevier
Introduction Arachidonoyl ethanolamide (AEA) and 2-arachidonoyl glycerol (2-AG) are
central lipid mediators of the endocannabinoid system. They are highly relevant due to their …

Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia

MMB Nielsen, KL Lambertsen, BH Clausen, M Meyer… - Scientific reports, 2016 - nature.com
Focal cerebral ischaemia has an initial phase of inflammation and tissue injury followed by a
later phase of resolution and repair. Mass spectrometry imaging (desorption electrospray …

Simultaneous UPLC–MS/MS quantification of the endocannabinoids 2-arachidonoyl glycerol (2AG), 1-arachidonoyl glycerol (1AG), and anandamide in human …

AA Zoerner, S Batkai, MT Suchy, FM Gutzki… - … of Chromatography B, 2012 - Elsevier
Analysis of the endocannabinoid (EC) system's key molecules 2-arachidonoyl glycerol
(2AG) and arachidonoyl ethanolamide (anandamide, AEA) is challenging due to several …

Estimation of reference intervals of five endocannabinoids and endocannabinoid related compounds in human plasma by two dimensional-LC/MS/MS

F Fanelli, VD Di Lallo, I Belluomo, R De Iasio… - Journal of lipid …, 2012 - ASBMB
The elucidation of the role of endocannabinoids in physiological and pathological conditions
and the transferability of the importance of these mediators from basic evidence into clinical …

The ratio of 2-AG to its isomer 1-AG as an intrinsic fine tuning mechanism of CB1 receptor activation

K Dócs, Z Mészár, S Gonda, A Kiss-Szikszai… - Frontiers in Cellular …, 2017 - frontiersin.org
Endocannabinoids are pleiotropic lipid messengers that play pro-homeostatic role in cellular
physiology by strongly influencing intracellular Ca2+ concentration through the activation of …

[HTML][HTML] Determination of the endocannabinoids anandamide and 2-arachidonoyl glycerol with gas chromatography-mass spectrometry: analytical and preanalytical …

C Lanz, J Mattsson, F Stickel, JF Dufour… - Medical Cannabis and …, 2018 - karger.com
Background: The endocannabinoids anandamide (N-arachidonoyl ethanolamide [AEA]) and
2-arachidonoyl glycerol (2-AG) are involved in the regulation of neuronal, immune …

Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences

S Higuchi, K Irie, R Yamaguchi, M Katsuki, M Araki… - PloS one, 2012 - journals.plos.org
Background In this study, we examined alterations in the hypothalamic reward system
related to high-fat diet (HFD) preferences. We previously reported that hypothalamic 2 …

Acyl migration of 2-monoacylglycerols rich in DHA: Effect of temperature and solvent medium

Y Zhang, X Wang, X Wang - Food Chemistry, 2023 - Elsevier
Abstract Acyl migration of 2-monoacylglycerols (2-MAGs) rich in DHA is a universal reaction
occurring during storage and structural lipid synthesis, and affects their nutritional value. In …

Surrogate analyte‐based quantification of main endocannabinoids in whole blood using liquid chromatography–tandem mass spectrometry

X Dong, L Li, Y Ye, D Zhang, L Zheng… - Biomedical …, 2019 - Wiley Online Library
Endocannabinoids (eCBs) are endogenous ligands of the endocannabinoid system that are
known to regulate several physiological and behavioral processes. Previous studies have …