[HTML][HTML] Phase separation in cancer: from the impacts and mechanisms to treatment potentials
Q Peng, S Tan, L Xia, N Wu, L Oyang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Cancer is a public health problem of great concern, and it is also one of the main causes of
death in the world. Cancer is a disease characterized by dysregulation of diverse cellular …
death in the world. Cancer is a disease characterized by dysregulation of diverse cellular …
[HTML][HTML] Nanomaterial-assisted CRISPR gene-engineering–A hallmark for triple-negative breast cancer therapeutics advancement
Triple-negative breast cancer (TNBC) is the most violent class of tumor and accounts for 20–
24% of total breast carcinoma, in which frequently rare mutation occurs in high frequency …
24% of total breast carcinoma, in which frequently rare mutation occurs in high frequency …
circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression
H Li, W Jiao, J Song, J Wang, G Chen, D Li… - Journal of Experimental …, 2023 - Springer
Background Recent evidence reveals the emerging functions of circular RNA (circRNA) and
protein glycosylation in cancer progression. However, the roles of circRNA in regulating …
protein glycosylation in cancer progression. However, the roles of circRNA in regulating …
NONO enhances mRNA processing of super‐enhancer‐associated GATA2 and HAND2 genes in neuroblastoma
S Zhang, JAL Cooper, YS Chong, A Naveed… - EMBO …, 2023 - embopress.org
High‐risk neuroblastoma patients have poor survival rates and require better therapeutic
options. High expression of a multifunctional DNA and RNA‐binding protein, NONO, in …
options. High expression of a multifunctional DNA and RNA‐binding protein, NONO, in …
[HTML][HTML] Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention
Background: Splicing factors are essential for nascent pre-mRNA processing and critical in
cancer progression, suggesting that proteins with splicing functions represent potential …
cancer progression, suggesting that proteins with splicing functions represent potential …
Liquid-liquid phase separation of DDR1 counteracts the Hippo pathway to orchestrate arterial stiffening
J Liu, J Wang, Y Liu, SA Xie, J Zhang, C Zhao… - Circulation …, 2023 - Am Heart Assoc
Background: The Hippo-YAP (yes-associated protein) signaling pathway is modulated in
response to various environmental cues. Activation of YAP in vascular smooth muscle cells …
response to various environmental cues. Activation of YAP in vascular smooth muscle cells …
Phase separation in chemical and mechanical signal transduction
Signal transduction enables cells to sense and respond to chemical and mechanical
information in the extracellular environment. Recently, phase separation has emerged as a …
information in the extracellular environment. Recently, phase separation has emerged as a …
Transcription factor condensates and signaling driven transcription
Transcription Factor (TF) condensates are a heterogenous mix of RNA, DNA, and multiple
co-factor proteins capable of modulating the transcriptional response of the cell. The …
co-factor proteins capable of modulating the transcriptional response of the cell. The …
Phase separation is required for PML nuclear body biogenesis and function
PML nuclear body (NB) malfunction often leads to acute leukemia outbreaks and other
severe diseases. PML NB rescue is the molecular basis of arsenic success in acute …
severe diseases. PML NB rescue is the molecular basis of arsenic success in acute …
New insights into the important roles of phase seperation in the targeted therapy of lung cancer
Y Zou, H Zheng, Y Ning, Y Yang, Q Wen, S Fan - Cell & Bioscience, 2023 - Springer
Lung cancer is a complex and heterogeneous disease characterized by abnormal growth
and proliferation of lung cells. It is the leading cause of cancer-related deaths worldwide …
and proliferation of lung cells. It is the leading cause of cancer-related deaths worldwide …