Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

Cytokinesis is the final step in cell division. The process begins during chromosome
segregation, when the ingressing cleavage furrow begins to partition the cytoplasm between …

Background Colorectal cancer (CRC) is the second leading cause of cancer deaths despite
the fact that detection of this cancer in early stages results in over 90% survival rate …

Anti‐angiogenic therapy has long been considered a promising strategy for solid cancers.
Intrinsic resistance to hypoxia is a major cause for the failure of anti‐angiogenic therapy, but …

Septins are a family of GTP-binding proteins implicated in mammalian cell division. Most
studies examining the role of septins in this process have treated the family as a whole, thus …

Septins are filamentous guanosine triphosphatase–binding proteins that are required for
cytokinesis in a wide range of organisms from yeast to man. Several septins, including …

Fast amoeboid migration is critical for developmental processes and can be hijacked by
cancer cells to enhance metastatic dissemination. This migratory behavior is tightly …

Background The septin 9 gene (SEPT9) codes for a GTP-binding protein associated with
filamentous structures and cytoskeleton formation. SEPT9 plays a role in multiple cancers as …

Septins are a family of GTP-binding proteins that assemble into cytoskeletal filaments.
Unlike other cytoskeletal components, septins form ordered arrays of defined stoichiometry …

Septins are conserved GTP-binding cytoskeletal proteins that polymerize into filaments by
end-to-end joining of hetero-oligomeric complexes. In human cells, both hexamers and …