Radiopharmaceutical therapy in cancer: clinical advances and challenges

G Sgouros, L Bodei, MR McDevitt… - Nature reviews Drug …, 2020 - nature.com
Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach
to treating many types of cancer. In RPT, radiation is systemically or locally delivered using …

Nucleic acid aptamers for molecular diagnostics and therapeutics: advances and perspectives

L Li, S Xu, H Yan, X Li, HS Yazd, X Li… - Angewandte Chemie …, 2021 - Wiley Online Library
The advent of SELEX (systematic evolution of ligands by exponential enrichment)
technology has shown the ability to evolve artificial ligands with affinity and specificity able to …

Inflammatory cytokines in cancer: comprehensive understanding and clinical progress in gene therapy

T Lan, L Chen, X Wei - Cells, 2021 - mdpi.com
The relationship between chronic inflammation and neoplastic diseases is not fully
understood. The inflammatory microenvironment of a tumor is an intricate network that …

Nanoparticle probes for the detection of cancer biomarkers, cells, and tissues by fluorescence

AB Chinen, CM Guan, JR Ferrer, SN Barnaby… - Chemical …, 2015 - ACS Publications
Cancer is the second most common cause of death in the United States, trailing only heart
disease in incidence. Despite significant worldwide investment in research, cancer remains …

Beyond the margins: real-time detection of cancer using targeted fluorophores

RR Zhang, AB Schroeder, JJ Grudzinski… - Nature reviews Clinical …, 2017 - nature.com
Over the past two decades, synergistic innovations in imaging technology have resulted in a
revolution in which a range of biomedical applications are now benefiting from fluorescence …

Smart injectable hydrogels for cancer immunotherapy

Y Chao, Q Chen, Z Liu - Advanced Functional Materials, 2020 - Wiley Online Library
Hydrogels, a class of materials with a 3D network structure, are widely used in various fields
especially in biomedicine. Injectable hydrogels could facilitate the encapsulation and …

Antibody therapy of cancer

AM Scott, JD Wolchok, LJ Old - Nature reviews cancer, 2012 - nature.com
The use of monoclonal antibodies (mAbs) for cancer therapy has achieved considerable
success in recent years. Antibody–drug conjugates are powerful new treatment options for …

Human serum albumin: from bench to bedside

G Fanali, A Di Masi, V Trezza, M Marino… - Molecular aspects of …, 2012 - Elsevier
Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric multi-
domain macromolecule, representing the main determinant of plasma oncotic pressure and …

Site-specific antibody drug conjugates for cancer therapy

S Panowski, S Bhakta, H Raab, P Polakis, JR Junutula - MAbs, 2014 - Taylor & Francis
Antibody therapeutics have revolutionized the treatment of cancer over the past two
decades. Antibodies that specifically bind tumor surface antigens can be effective …

An overview of clinical and commercial impact of drug delivery systems

AC Anselmo, S Mitragotri - Journal of Controlled Release, 2014 - Elsevier
Drug delivery systems are widely researched and developed to improve the delivery of
pharmaceutical compounds and molecules. The last few decades have seen a marked …