Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

Claudins are a tetraspan membrane protein multigene family that plays a structural and
functional role in constructing tight junctions. Claudins perform crucial roles in maintaining …

Background We conducted comprehensive clinical and molecular characterization of
claudin 18.2 expression (CLDN18. 2) in advanced gastric or gastroesophageal junction …

Claudins are major components of tight junctions that maintain cell polarity and intercellular
adhesion. The dynamics of claudins in cancer cells have attracted attention as a therapeutic …

Abstract Claudin 18.2, a tight-junction molecule predominantly found in the nonmalignant
gastric epithelium, becomes accessible on the tumour cell surface during malignant …

Resectable gastric or gastroesophageal (G/GEJ) cancer is a heterogeneous disease with no
defined molecularly based treatment strategy. Unfortunately, nearly half of patients …

Gastric cancer (GC) remains one of the most common deadly malignancies worldwide.
Recently, several targeted therapeutics for treating unresectable or metastatic GC have …

Abstract Claudin 18.2 (CLDN18. 2), the dominant isoform of CLDN18 in gastric tissue, is a
highly specific tight junction protein of the gastric mucosa with variably retained expression …

Simple Summary Gastric cancer (GC) is common but often diagnosed late. Recent advances
in chemotherapy, targeted therapy, and immunotherapy offer promising treatments …

Claudins (CLDNs) are a family of major membrane proteins that form components of tight
junctions. In normal tissues, CLDNs seal the intercellular space in the epithelial sheets to …