Oxidative stress and inflammation interact in the development of diabetic atherosclerosis.
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …

adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an evolutionarily
conserved serine/threonine kinase that was originally identified as the key player in …

Obesity is an important aspect of the metabolic syndrome and is often associated with
chronic inflammation. In this context, inflammation of organs participating in energy …

The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …

The peroxisome proliferator-activated receptor (PPAR) family includes three transcription
factors: PPARα, PPARβ/δ, and PPARγ. PPAR are nuclear receptors activated by oxidised …

Recent studies have indicated that the regulation of innate immunity and energy metabolism
are connected together through an antagonistic crosstalk between NF-κB and SIRT1 …

Insulin resistance (IR) and hyperinsulinemia are hallmarks of the metabolic syndrome, as
are central adiposity, dyslipidemia, and a predisposition to type 2 diabetes, atherosclerotic …

High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2
diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance, yet how IL-1β is induced …

Efficient control of energy metabolic homeostasis, enhanced stress resistance, and qualified
cellular housekeeping are the hallmarks of improved healthspan and extended lifespan …

Interactions between macrophages and adipocytes influence both metabolism and
inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic …