Apigenin: A current review on its beneficial biological activities

X Zhou, F Wang, R Zhou, X Song… - Journal of Food …, 2017 - Wiley Online Library
Abstract Apigenin, identified as 4′, 5, 7‐trihydroxyflavone, is a natural flavonoid compound
present in a variety of fruits, vegetables, functional foods, and medicinal plants. Many studies …

Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways

S Malik, K Suchal, SI Khan, J Bhatia… - American Journal …, 2017 - journals.physiology.org
Diabetic nephropathy (DN), a microvascular complication of diabetes, has emerged as an
important health problem worldwide. There is strong evidence to suggest that oxidative …

Naturally plant-derived compounds: role in bone anabolism

MN Horcajada, E Offord - Current molecular pharmacology, 2012 - ingentaconnect.com
From a nutritional point of view, several factors are involved in ensuring optimal bone health.
The most documented of these are calcium and vitamin D. However, it is now well …

Cellular hypoxia promotes heterotopic ossification by amplifying BMP signaling

H Wang, C Lindborg, V Lounev, JH Kim… - Journal of Bone and …, 2016 - academic.oup.com
Hypoxia and inflammation are implicated in the episodic induction of heterotopic
endochondral ossification (HEO); however, the molecular mechanisms are unknown. HIF …

The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss

TH Kim, JW Jung, BG Ha, JM Hong, EK Park… - The Journal of nutritional …, 2011 - Elsevier
Flavonoids, a group of polyphenolic compounds abundant in plants, are known to prevent
bone loss in ovariectomized (OVX) animal models. Inhibition of osteoclast differentiation and …

Cissus quadrangularis (Hadjod) Inhibits RANKL-Induced Osteoclastogenesis and Augments Bone Health in an Estrogen-Deficient Preclinical Model of Osteoporosis …

Z Azam, L Sapra, K Baghel, N Sinha, RK Gupta, V Soni… - Cells, 2023 - mdpi.com
Osteoporosis is a systemic skeletal disease characterised by low bone mineral density
(BMD), degeneration of bone micro-architecture, and impaired bone strength. Cissus …

Apigenin promotes osteogenic differentiation of mesenchymal stem cells and accelerates bone fracture healing via activating Wnt/β-catenin signaling

F Pan, J Shao, CJ Shi, Z Li, W Fu… - American Journal of …, 2021 - journals.physiology.org
Apigenin (API), a natural plant flavone, is abundantly found in common fruits and
vegetables. As a bioactive flavonoid, API exhibits several activities including antiproliferation …

Antiosteoporotic effect of hesperidin against ovariectomy‐induced osteoporosis in rats via reduction of oxidative stress and inflammation

Q Zhang, X Song, X Chen, R Jiang… - … of biochemical and …, 2021 - Wiley Online Library
Osteoporosis is a serious health problem, especially in geriatric patients. Worldwide, it
affects 8.9 million people every year. Oxidative stress and inflammation expand the …

Apigenin inhibits osteoblastogenesis and osteoclastogenesis and prevents bone loss in ovariectomized mice

T Goto, K Hagiwara, N Shirai, K Yoshida, H Hagiwara - Cytotechnology, 2015 - Springer
Polyphenol have been reported to have physiological effects with respect to alleviating
diseases such as osteoporosis and osteopetrosis. We recently reported that the olive …

Anti-osteoporosis activity of Cibotium barometz extract on ovariectomy-induced bone loss in rats

X Zhao, ZX Wu, Y Zhang, YB Yan, Q He, PC Cao… - Journal of …, 2011 - Elsevier
abstract Ethnopharmacological relevance: Recent research has confirmed that Cibotium
barometz could inhibits osteoclast formation with no affect on BMM cell viability. However …