Vision loss from ischemic retinopathies commonly results from the accumulation of fluid in
the inner retina [macular edema (ME)]. Although the precise events that lead to the …

In proliferative diabetic retinopathy (PDR), retinal ischemia promotes neovascularization
(NV), which can lead to profound vision loss in diabetic patients. Treatment for PDR …

Growth cones at the tips of extending axons navigate through developing organisms by
probing extracellular cues, which guide them through intermediate steps and onto final …

Twenty-two tandemly arranged protocadherin-γ (Pcdh-γ) genes encode transmembrane
proteins with distinct cadherin-related extracellular domains and a common intracellular …

Ciliary neurotrophic factor (CNTF) acts in several processes in the vertebrate retina,
including neuroprotection of photoreceptors in the stressed adult retina and regulation of …

Background: The development of highly scalable single-cell transcriptome technology has
resulted in the creation of thousands of datasets,> 30 in the retina alone. Analyzing the …

Ciliary neurotrophic factor (CNTF) acts as a potent neuroprotective cytokine in multiple
models of retinal degeneration. To understand mechanisms underlying its broad …

Norrin is a retinal signaling molecule which is expressed in Müller glia and binds to Frizzled-
4 to activate canonical Wnt/β-catenin signaling. Norrin is part of an essential signaling …

The Akt kinases mediate cell survival through phosphorylation and inactivation of apoptotic
machinery components. Akt signaling provides a trophic signal for transformed retinal …

Ciliary neurotrophic factor (CNTF) protects photoreceptors and regulates their
phototransduction machinery, but little is known about CNTF's effects on retinal pigment …