Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future

Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives

Y Cheng, DY Tian, YJ Wang - Translational neurodegeneration, 2020 - Springer
Alzheimer's disease (AD) is the most common type of dementia, and no disease-modifying
treatments are available to halt or slow its progression. Amyloid-beta (Aβ) is suggested to …

Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein

H Jung, SY Lee, S Lim, HR Choi, Y Choi, M Kim… - Nature Medicine, 2022 - nature.com
Clearing amyloid-β (Aβ) through immunotherapy is one of the most promising therapeutic
approaches to Alzheimer's disease (AD). Although several monoclonal antibodies against …

Neurovascular alterations in vascular dementia: emphasis on risk factors

S Lecordier, D Manrique-Castano… - Frontiers in aging …, 2021 - frontiersin.org
Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the
world after Alzheimer's disease (AD). VaD regroups heterogeneous neurological conditions …

Carnosine protects macrophages against the toxicity of aβ1-42 oligomers by decreasing oxidative stress

G Caruso, C Benatti, N Musso, CG Fresta, A Fidilio… - Biomedicines, 2021 - mdpi.com
Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous peptide widely
distributed in excitable tissues such as the brain. This dipeptide has well-known antioxidant …

Tau-directed immunotherapy: a promising strategy for treating Alzheimer's disease and other tauopathies

SK Schroeder, A Joly-Amado, MN Gordon… - Journal of neuroimmune …, 2016 - Springer
Immunotherapy directed against tau is a promising treatment strategy for Alzheimer's
Disease (AD) and tauopathies. We review initial studies on tau-directed immunotherapy …

[HTML][HTML] Sensory Gamma Entrainment: Impact on amyloid protein and Therapeutic mechanism

J Hu, L Zheng, Z Guan, K Zhong, F Huang… - Brain Research …, 2023 - Elsevier
The deposition of amyloid β peptide (Aβ) is one of the main pathological features of AD. The
much-talked sensory gamma entrainment may be a new treatment for Aβ load. Here we …

[HTML][HTML] DHA attenuates Aβ-induced necroptosis through the RIPK1/RIPK3 signaling pathway in THP-1 monocytes

S Yuan, H Li, C Yang, W Xie, Y Wang, J Zhang… - Biomedicine & …, 2020 - Elsevier
Monocytes play a crucial role in Alzheimer's disease (AD), and docosahexaenoic acid
(DHA) has a neuroprotective effect for many neurodegenerative diseases. However …

More than microglia: myeloid cells and biomarkers in neurodegeneration

E Kodosaki, R Bell, A Sogorb-Esteve… - Frontiers in …, 2024 - frontiersin.org
The role of myeloid cells (granulocytes and monocytes) in neurodegeneration and
neurodegenerative disorders (NDD) is indisputable. Here we discuss the roles of myeloid …

Monocytes in the Peripheral Clearance of Amyloid-β and Alzheimer's Disease

H Guo, Z Zhao, R Zhang, P Chen… - Journal of …, 2019 - content.iospress.com
Aging societies have high incidence rates of Alzheimer's disease (AD). AD is diagnosed at
later disease stages and has a poor prognosis, and effective drugs and treatments for AD …