The 2022 WHO classification of tumors of the pituitary gland: An update on aggressive and metastatic pituitary neuroendocrine tumors
O Casar‐Borota, P Burman, MB Lopes - Brain Pathology, 2024 - Wiley Online Library
The vast majority of pituitary neuroendocrine tumors (PitNETs) are benign and slow growing
with a low relapse rate over many years after surgical resection. However, about 40% are …
with a low relapse rate over many years after surgical resection. However, about 40% are …
Genomics, Transcriptomics, and Epigenetics of Sporadic Pituitary Tumors
D Marrero-Rodríguez, S Vela-Patiño… - Archives of Medical …, 2023 - Elsevier
Pituitary tumors (PT) are highly heterogeneous neoplasms, comprising functioning and
nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea …
nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea …
Single-cell transcriptomic analysis reveals tumor cell heterogeneity and immune microenvironment features of pituitary neuroendocrine tumors
Abstract Background Pituitary neuroendocrine tumors (PitNETs) are one of the most
common types of intracranial tumors. Currently, the cellular characteristics of normal pituitary …
common types of intracranial tumors. Currently, the cellular characteristics of normal pituitary …
FTO-mediated DSP m6A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors
Y Zou, X Bao, D Li, Z Ye, R Xiang, Y Yang, Z Zhu… - Molecular Cancer, 2024 - Springer
Background Growth hormone-secreting pituitary neuroendocrine tumors can be
pathologically classified into densely granulated (DGGH) and sparsely granulated types …
pathologically classified into densely granulated (DGGH) and sparsely granulated types …
Erythropoietin-producing hepatocellular receptor B6 is highly expressed in non-functioning pituitary neuroendocrine tumors and its expression correlates with tumor …
H Rubinfeld, ZR Cohen, U Bendavid… - Molecular biology …, 2024 - Springer
Background Erythropoietin-producing hepatocellular (EPH) receptors are the largest known
family of receptor tyrosine kinases characterized in humans. These proteins are involved in …
family of receptor tyrosine kinases characterized in humans. These proteins are involved in …
Single-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage–tumor interaction axes among different lineages of pituitary …
Abstract Background Pituitary neuroendocrine tumors (PitNETs) are common gland
neoplasms demonstrating distinctive transcription factors. Although the role of immune cells …
neoplasms demonstrating distinctive transcription factors. Although the role of immune cells …
The molecular biology of sporadic acromegaly
D Marrero-Rodríguez, A Moscona-Nissan… - Best Practice & …, 2024 - Elsevier
GH-secreting tumors represent 15% to 20% of all pituitary neuroendocrine tiumors
(pitNETs), of which 95% occur in a sporadic context, without an identifiable inherited cause …
(pitNETs), of which 95% occur in a sporadic context, without an identifiable inherited cause …
Longitudinal multiomics analysis of aggressive pituitary neuroendocrine tumors: comparing primary and recurrent tumors from the same patient, reveals genomic …
K Taniguchi-Ponciano, S Hinojosa-Alvarez… - Acta Neuropathologica …, 2024 - Springer
Pituitary neuroendocrine tumors (PitNET) represent the vast majority of sellar masses. Some
behave aggressively, growing rapidly and invading surrounding tissues, with high rates of …
behave aggressively, growing rapidly and invading surrounding tissues, with high rates of …
PCSK1N as a tumor size marker and an ER stress response protein in corticotroph pituitary adenomas
M Abusdal, KR Normann, TA Nyman… - The Journal of …, 2024 - academic.oup.com
Context Silent corticotroph adenoma (SCA) exhibits more tumor aggressiveness features
than functioning adenomas (FCAs). Objective We aimed to investigate proprotein …
than functioning adenomas (FCAs). Objective We aimed to investigate proprotein …
Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET
TE Potthoff, C Walter, D Jeising, D Münter… - Journal of translational …, 2024 - Springer
Abstract Background Pituitary neuroendocrine tumors (PitNET) are among the most common
intracranial tumors. Despite a frequent benign course, aggressive behavior can occur …
intracranial tumors. Despite a frequent benign course, aggressive behavior can occur …