Novel lead compounds in pre-clinical development against African sleeping sickness

M Berninger, I Schmidt, A Ponte-Sucre… - MedChemComm, 2017 - pubs.rsc.org
Human African trypanosomiasis (HAT), also known as African sleeping sickness, is caused
by parasitic protozoa of the genus Trypanosoma. As the disease progresses, the parasites …

In silico evaluation and in vitro growth inhibition of Plasmodium falciparum by natural amides and synthetic analogs

MA da Silva, MP Veloso, K de Souza Reis… - Parasitology …, 2020 - Springer
Malaria, caused by protozoa of the genus Plasmodium, is a disease that infects hundreds of
millions of people annually, causing an enormous social burden in many developing …

Novel triazine dimers with potent antitrypanosomal activity

M Venkatraj, IG Salado, J Heeres, J Joossens… - European journal of …, 2018 - Elsevier
Human African trypanosomiasis (HAT), also known as sleeping sickness is a parasitic
disease transmitted by the bite of the'Glossina'insect, commonly known as the tsetse fly. This …

Design, synthesis, and antitumor evaluation of novel naphthalimide derivatives

X Li, Z Wu, L Xu, CL Chi, BQ Chen - Medicinal Chemistry Research, 2020 - Springer
In order to research the structure–activity relationships of novel naphthalimide derivatives
bearing disulfide bond toward antitumor activity, we prepared a series of those and their in …

New Compounds for the Management of Trypanosoma brucei Infection

G Luisi, S Carradori - Antiprotozoal Drug Development and Delivery, 2021 - Springer
The protozoan parasite Trypanosoma brucei causes human African trypanosomiasis (HAT),
a fatal and neglected disease in the tropic areas. Owing to the scarcity of investments, new …

Role of computational efficiency indices and pose clustering in effective decision making: an example of annulated furanones in Pf-DHFR space

M Kumar, T Kaur, A Sharma - Computational Biology and Chemistry, 2017 - Elsevier
In the present report, the role of computationally estimated efficiency indices and pose
clustering has been demonstrated in effective decision making, resource management and …

Propiedades químicas estructurales de compuestos que actúan contra el Trypanosoma brucei (Revisión)

A Ponte-Sucre - Vitae, 2015 - saber.ucv.ve
Se resume en este artículo la labor incansable que durante doce años se ha realizado en el
marco de un proyecto multicéntrico, liderado principalmente por los Prof. Jörg Hacker, Ulrike …

Adaptability and flexibility, paradigms of survival in Leishmania parasites

A Ponte-Sucre, M Padrón Nieves, E Díaz-López - saber.ucv.ve
The Molecular Physiology Laboratory was created in 1994, a few months upon the return of
Alicia Ponte-Sucre (APS) to the Chair of Physiology, after completing her Doctorate in …

Celebración de los 20 años del Laboratorio de Fisiología Molecular

A Ponte-Sucre, M Padrón-Nieves, E Diaz - saber.ucv.ve
La carrera académica de Alicia Ponte-Sucre (APS) comenzó en 1981, cuando ingresó como
Profesor Instructor en el Departamento de Ciencias Fisiológicas de la Facultad de Medicina …

[PDF][PDF] Antileishmanial and antitrypanosomal compounds from\(Achillea\)\(fragrantissima\)

J Skaf - 2018 - opus.bibliothek.uni-wuerzburg.de
Antileishmanial and antitrypanosomal compounds from Achillea fragrantissima Page 1
Antileishmanial and antitrypanosomal compounds from Achillea fragrantissima Dissertation zur …