Alzheimer's disease (AD) manifests along a spectrum of cognitive deficits and levels of
neuropathology. Genetic studies support a heterogeneous disease mechanism, with around …

The clinical definition of neurodegenerative diseases is based on symptoms that reflect
terminal damage of specific brain regions. This is misleading as it tells little about the initial …

Microglia and neuroinflammation play an important role in the development and progression
of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a …

Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …

The relationship between genetic variation and gene expression in brain cell types and
subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data …

Alphaviruses, like many other arthropod-borne viruses, infect vertebrate species and insect
vectors separated by hundreds of millions of years of evolutionary history. Entry into …

Biological aging can be described as accumulative, prolonged metabolic stress and is the
major risk factor for cognitive decline and Alzheimer's disease (AD). Recently, we identified …

Aging is the biggest risk factor for the development of Alzheimer's disease (AD). Here, we
performed a whole-genome CRISPR screen to identify regulators of neuronal age and show …

MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets
and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be …

SORL1 is implicated in the pathogenesis of Alzheimer's disease (AD) through genetic
studies. To interrogate the roles of SORL1 in human brain cells, SORL1-null induced …