Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic …

A Yim, C Smith, AM Brown - Immunological reviews, 2022 - Wiley Online Library
Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1
(SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that …

[HTML][HTML] Mechanosensation in traumatic brain injury

CE Keating, DK Cullen - Neurobiology of disease, 2021 - Elsevier
Traumatic brain injury (TBI) is distinct from other neurological disorders because it is
induced by a discrete event that applies extreme mechanical forces to the brain. This review …

Extracellular vesicles set the stage for brain plasticity and recovery by multimodal signalling

DM Hermann, L Peruzzotti-Jametti, B Giebel… - Brain, 2024 - academic.oup.com
Extracellular vesicles (EVs) are extremely versatile naturally occurring membrane particles
that convey complex signals between cells. EVs of different cellular sources are capable of …

Regulation of the hippocampal translatome by Apoer2-ICD release

CR Wasser, GC Werthmann, EM Hall… - Molecular …, 2023 - Springer
Background ApoE4, the most significant genetic risk factor for late-onset Alzheimer's disease
(AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal …

To stick or not to stick: The multiple roles of cell adhesion molecules in neural circuit assembly

T Moreland, FE Poulain - Frontiers in Neuroscience, 2022 - frontiersin.org
Precise wiring of neural circuits is essential for brain connectivity and function. During
development, axons respond to diverse cues present in the extracellular matrix or at the …

Di-(2-ethylhexyl) phthalate exposure impairs cortical development in hESC-derived cerebral organoids

L Yang, J Zou, Z Zang, L Wang, Z Du, D Zhang… - Science of The Total …, 2023 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP), a ubiquitous environmental endocrine
disruptor, is widely used in consumer products. Increasing evidence implies that DEHP …

Interactions of amyloid-β with membrane proteins

B Wiatrak, J Piasny, A Kuźniarski… - International journal of …, 2021 - mdpi.com
In developing and developed countries, an increasing elderly population is observed. This
affects the growing percentage of people struggling with neurodegenerative diseases …

Integrin signaling in the central nervous system in animals and human brain diseases

H Ikeshima-Kataoka, C Sugimoto… - International journal of …, 2022 - mdpi.com
The integrin family is involved in various biological functions, including cell proliferation,
differentiation and migration, and also in the pathogenesis of disease. Integrins are …

The role of cell adhesion molecule IgSF9b at the inhibitory synapse and psychiatric disease

JD Clarin, N Reddy, C Alexandropoulos… - … & Biobehavioral Reviews, 2024 - Elsevier
Understanding perturbations in synaptic function between health and disease states is
crucial to the treatment of neuropsychiatric illness. While genome-wide association studies …

The involvement of semaphorin 7A in tumorigenic and immunoinflammatory regulation

Y Song, L Wang, L Zhang… - Journal of Cellular …, 2021 - Wiley Online Library
Semaphorins, a large group of highly conserved proteins, consist of eight subfamilies that
are widely expressed in vertebrates, invertebrates, and viruses and exist in membrane …