Cell death is an essential biological process for physiological growth and development.
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …

Programmed cell death (PCD) or apoptosis is a mechanism which is crucial for all
multicellular organisms to control cell proliferation and maintain tissue homeostasis as well …

Cells can respond to stress in various ways ranging from the activation of survival pathways
to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a …

Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …

One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis.
Evasion of apoptosis may contribute to carcinogenesis, tumor progression and also to …

Abstract Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a
master anti-apoptotic regulator and resistance factor that suppresses tumor necrosis factor-α …

Rationale: During acute lung injury (ALI) the macrophage pool expands markedly as
inflammatory monocytes migrate from the circulation to the airspaces. As inflammation …

Betulinic acid is a natural product with a range of biological effects, for example potent
antitumor activity. This anticancer property is linked to its ability to induce apoptotic cell …

Tumor necrosis factor (TNF), initially reported to induce tumor cell apoptosis and cachexia, is
now considered a central mediator of a broad range of biological activities from cell …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the
TNF family that induces cancer cell death by apoptosis with some selectivity. TRAIL-induced …