Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …

Cytidine diphosphate diacylglycerol (CDP-DAG) is a key intermediate in the synthesis of
phosphatidylinositol (PI) and cardiolipin (CL). Both PI and CL have highly specialized roles …

Host cell exit is a critical step in the life-cycle of intracellular pathogens, intimately linked to
barrier penetration, tissue dissemination, inflammation, and pathogen transmission. Like cell …

Metabolic pathways underpin the growth and virulence of intracellular parasites and are
therefore promising antiparasitic targets. The pentose phosphate pathway (PPP) is vital in …

Toxoplasma gondii is a prevalent zoonotic pathogen infecting livestock as well as humans.
The exceptional ability of this parasite to reproduce in several types of nucleated host cells …

Abstract Ribose-5-phosphate (R5P) is a precursor for nucleic acid biogenesis; however, the
importance and homeostasis of R5P in the intracellular parasite Toxoplasma gondii remain …

Apicomplexa are obligate intracellular parasites responsible for major human diseases.
Their intracellular survival relies on intense lipid synthesis, which fuels membrane …

The roles of lipids expand beyond the basic building blocks of biological membranes. In
addition to forming complex and dynamic barriers, the thousands of different lipid species in …

Lipid membranes are the border between living cells and their environments. The
membrane's lipid composition defines fluidity, thickness, and protein activity and is …

The cellular membranes of Trypanosoma cruzi, like all eukaryotes, contain varying amounts
of phospholipids, sphingolipids, neutral lipids and sterols. A multitude of pathways exist for …