Chemokines from a structural perspective

MC Miller, KH Mayo - International journal of molecular sciences, 2017 - mdpi.com
Chemokines are a family of small, highly conserved cytokines that mediate various
biological processes, including chemotaxis, hematopoiesis, and angiogenesis, and that …

The structure of glycosaminoglycans and their interactions with proteins

NS Gandhi, RL Mancera - Chemical biology & drug design, 2008 - Wiley Online Library
Glycosaminoglycans (GAGs) are important complex carbohydrates that participate in many
biological processes through the regulation of their various protein partners. Biochemical …

CXCR4/CXCL12 activities in the tumor microenvironment and implications for tumor immunotherapy

R Mezzapelle, M Leo, F Caprioglio, LS Colley… - Cancers, 2022 - mdpi.com
Simple Summary Chemokines are small soluble proteins that control and regulate cell
trafficking within and between tissues by binding to their receptors. Among them, CXCL12 …

Targeting chemokine—glycosaminoglycan interactions to inhibit inflammation

H Crijns, V Vanheule, P Proost - Frontiers in immunology, 2020 - frontiersin.org
Leukocyte migration into tissues depends on the activity of chemokines that form
concentration gradients to guide leukocytes to a specific site. Interaction of chemokines with …

Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12

CT Veldkamp, C Seibert, FC Peterson… - Science …, 2008 - science.org
Stem cell homing and breast cancer metastasis are orchestrated by the chemokine stromal
cell–derived factor 1 (SDF-1) and its receptor CXCR4. Here, we report the nuclear magnetic …

Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells' response to Pten deletion

L Xie, LP Cen, Y Li, HY Gilbert… - Proceedings of the …, 2022 - National Acad Sciences
Although mammalian retinal ganglion cells (RGCs) normally cannot regenerate axons nor
survive after optic nerve injury, this failure is partially reversed by inducing sterile …

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

LJ Drury, JJ Ziarek, S Gravel… - Proceedings of the …, 2011 - National Acad Sciences
Chemokines and chemokine receptors are extensively and broadly involved in cancer
metastasis. Previously, we demonstrated that epigenetic silencing of the chemokine …

CXCR7 impact on CXCL12 biology and disease

L Sánchez-Martín, P Sánchez-Mateos… - Trends in molecular …, 2013 - cell.com
It is known that the chemokine receptor CXCR7 (RDC1) can be engaged by both
chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and …

[HTML][HTML] Alginate-microencapsulation of human stem cell–derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic …

DA Alagpulinsa, JJL Cao, RK Driscoll… - American Journal of …, 2019 - Elsevier
Pancreatic β-cell replacement by islet transplantation for the treatment of type 1 diabetes
(T1D) is currently limited by donor tissue scarcity and the requirement for lifelong …

Facile synthesis and characterization of disulfide-cross-linked hyaluronic acid hydrogels for protein delivery and cell encapsulation

SY Choh, D Cross, C Wang - Biomacromolecules, 2011 - ACS Publications
Injectable hyaluronic acid (HA) hydrogels cross-linked via disulfide bond are synthesized
using a thiol− disulfide exchange reaction. The production of small-molecule reaction …