In proteomics, nano-LC is arguably the most common tool for separating peptides/proteins
prior to MS. The main advantage of nano-LC is enhanced sensitivity, as compounds enter …

Cell adhesion and stable signaling regulation are fundamental ways of maintaining
homeostasis. Among them, the Wnt/β-CATENIN signaling plays a key role in embryonic …

The Wnt/β-catenin signaling pathway is indispensable for embryonic development,
maintenance of adult tissue homeostasis and repair of epithelial injury. Unsurprisingly …

Aberrant Wnt signaling frequently occurs in pancreatic cancer (PC) and contributes to
disease progression/metastases. Likewise, the transmembrane-mucin MUC4 is expressed …

Aim: We compared four commonly used, commercially available reverse phase nanoLC
columns for identification/determination of Wnt/β-catenin-related pathway proteins. Materials …

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with intrinsic
resistance to cytotoxic agents. The molecular mechanisms associated with high malignancy …

Abstract β-CATENIN is an evolutionarily conserved multifunctional molecule that maintains
cell adhesion as a cell junction protein to safeguard the integrity of the mammalian blood …

Capillary liquid chromatography-mass spectrometry (cLC-MS) is a powerful tool for a variety
of applications in analytical chemistry. Key advantages of cLC-MS are its suitability for small …

Mass spectrometry coupled to nanoliquid chromatography aims to be an alternative to
antibody-based determination of low-abundant proteins. High-resolution mass …

基因组编辑技术是位点特异性基因靶向操作的重要工具, 研究者可通过该技术实现对感兴趣的
目标基因或DNA 片段进行" 编辑", 实现对靶DNA 的定点敲除, 敲入等基因组改造 …