Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1,
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …

Although the currently available antidiabetic medications are effective in managing
hyperglycemia, vascular complications are common in diabetic patients. Cohort studies …

Diabetes mellitus type 1 and type 2 have become a global epidemic with dramatically
increasing incidences. Poorly controlled diabetes is associated with severe life-threatening …

γ-Aminobutyric acid (GABA) exerts protective and regenerative effects on mouse islet β-
cells. However, in humans it is unknown whether it can increase β-cell mass and improve …

Elucidating the mechanism underlying the poor proliferative capacity of adult pancreatic β-
cells is critical to regenerative therapeutic approaches for diabetes. Here, we show that the …

MicroRNAs (miRNA) are small non-coding RNAs that inhibit gene expression through
binding to complementary messenger RNA sequences. miRNAs have been predicted to …

The serine/threonine kinase AKT functions as a critical mediator of signaling downstream of
PI3 kinase. Studies over the last two decades have firmly established the importance of AKT …

To overcome the limitations of the clinical use of neurotrophins nerve growth factor (NGF)
and brain‐derived neurotrophic factor (BDNF), scientists have been trying to create their low …

Aims Caffeic acid, naringenin and quercetin are naturally occurring phenolic compounds
(PCs) present in many plants as secondary metabolites. The aim of this study was to …

Background: Diabetes is an increasingly prevalent global disease caused by the impairment
in insulin production or insulin function. Diabetes in the long term causes both microvascular …