Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-
associated variants with diverse genomic and biological data sets to provide insight into …

Identifying the downstream effects of disease-associated SNPs is challenging. To help
overcome this problem, we performed expression quantitative trait locus (eQTL) meta …

BACKGROUND: Findings from family and twin studies suggest that genetic contributions to
psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to …

Our understanding of celiac disease and how it develops has evolved significantly over the
last half century. Although traditionally viewed as a pediatric illness characterized by …

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-
analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets …

The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …

Study of the genetics of rheumatoid arthritis (RA) began about four decades ago with the
discovery of HLA-DRB1. Since the beginning of this century, a number of non-HLA risk loci …

The genetic association of the major histocompatibility complex (MHC) to rheumatoid
arthritis risk has commonly been attributed to alleles in HLA-DRB1. However, debate …