The spliceosome is a highly complex, dynamic ribonucleoprotein molecular machine that
undergoes numerous structural and compositional rearrangements that lead to the formation …

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and
isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to …

Although cyclophilins are attractive targets for probing biology and therapeutic intervention,
no subtype-selective cyclophilin inhibitors have been described. We discovered novel …

Abstract Methyltransferase-like 3 (METTL3) is the catalytic subunit of the N 6-adenosine
methyltransferase complex responsible for N 6-methyladenosine (m6A) modification of …

Secondary hyperparathyroidism (SHP) is a common complication of chronic kidney disease
(CKD) that induces morbidity and mortality in patients. How CKD stimulates the parathyroid …

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is an evolutionally conserved
and unique enzyme that specifically catalyzes the cis-trans isomerization of phosphorylated …

The highly conserved family of cyclophilins comprises multifunctional chaperones that
interact with proteins and RNAs, facilitating the dynamic assembly of multimolecular …

Translation of consecutive prolines causes ribosome stalling, which is alleviated but cannot
be fully compensated by the elongation factor P. However, the presence of polyproline …

Nuclear bodies are diverse membraneless suborganelles with emerging links to
development and disease. Explaining their structure, function, regulation, and implications in …

Parathyroid hormone (PTH) regulates serum calcium levels and bone strength. Secondary
hyperparathyroidism (SHP) is a common complication of chronic kidney disease (CKD) that …