Adipose-derived mesenchymal stem cells therapy as a new treatment option for diabetes mellitus

A Mikłosz, A Chabowski - The Journal of Clinical Endocrinology …, 2023 - academic.oup.com
The worldwide increase in the prevalence of diabetes mellitus has raised the demand for
new therapeutic strategies targeting diabetic symptoms and its chronic complications …

A Narrative Review of Diabetic Macroangiopathy: From Molecular Mechanism to Therapeutic Approaches

J Yin, X Fu, Y Luo, Y Leng, L Ao, C Xie - Diabetes Therapy, 2024 - Springer
Diabetic macroangiopathy, a prevalent and severe complication of diabetes mellitus,
significantly contributes to the increased morbidity and mortality rates among affected …

Baihu renshen decoction ameliorates type 2 diabetes mellitus in rats through affecting gut microbiota enhancing gut permeability and inhibiting TLR4/NF-κB-mediated …

B Yao, B Pan, T Tian, X Su, S Zhang, H Li… - Frontiers in Cellular …, 2022 - frontiersin.org
Baihu Rensheng decoction (BHRS) can effectively improve insulin resistance (IR) and
decrease blood glucose in diabetic patients. However, its specific mechanism of action …

Human Placental Mesenchymal Stem Cells Relieve Primary Sclerosing Cholangitis via Upregulation of TGR5 in Mdr2−/− Mice and Human Intrahepatic …

Q Yao, W Chen, Y Yu, F Gao, J Zhou, J Wu, Q Pan… - Research, 2023 - spj.science.org
Primary sclerosing cholangitis (PSC) is a biliary disease accompanied by chronic
inflammation of the liver and biliary stricture. Mesenchymal stem cells (MSCs) are used to …

Melatonin promotes the therapeutic effect of mesenchymal stem cells on Type 2 diabetes mellitus by regulating TGF-β pathway

B Li, X Cheng, A Aierken, J Du, W He… - Frontiers in Cell and …, 2021 - frontiersin.org
Abundant evidence proves the therapeutic effect of adipose-derived mesenchymal stem
cells (ADMSCs) in the treatment of diabetes mellitus. However, the problems have not been …

Human adipose-derived stem cell-loaded small intestinal submucosa as a bioactive wound dressing for the treatment of diabetic wounds in rats

YL Jiang, ZL Wang, ZX Fan, MJ Wu, Y Zhang… - Biomaterials …, 2022 - Elsevier
Chronic nonhealing wounds are one of the most common and serious complications of
diabetes, which can lead to disability of patients. Adipose-derived stem cells (ADSCs) have …

Therapeutic Potential of Mesenchymal Stem Cell‐Derived Conditioned Medium for Diabetes Mellitus and Related Complications

B Isildar, S Ozkan, M Koyuturk - Advanced Therapeutics, 2023 - Wiley Online Library
Diabetes mellitus (DM) is one of the most life‐threatening metabolic disorders, with 9% of
the global prevalence, and it is estimated to be rising to 12.2% in 2045. Currently, there is no …

Human umbilical cord-derived mesenchymal stem cells alleviate oxidative stress-induced islet impairment via the Nrf2/HO-1 axis

P Liu, B Cao, Y Zhou, H Zhang… - Journal of Molecular Cell …, 2023 - academic.oup.com
Hyperglycaemia-induced oxidative stress may disrupt insulin secretion and β-cell survival in
diabetes mellitus by overproducing reactive oxygen species. Human umbilical cord-derived …

Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications

L Li, S Hua, L You, T Zhong - Current Stem Cell Research & …, 2024 - benthamdirect.com
Diabetes is a complex metabolic disease with a high global prevalence. The health and
quality of life of patients with diabetes are threatened by many complications, including …

Treatment of type 2 diabetes mellitus with stem cells and antidiabetic drugs: a dualistic and future-focused approach

PA Arte, K Tungare, M Bhori, R Jobby, J Aich - Human Cell, 2024 - Springer
Abstract Type 2 Diabetes Mellitus (T2DM) accounts for more than 90% of total diabetes
mellitus cases all over the world. Obesity and lack of balance between energy intake and …