Drought and salinity are among the most important environmental factors that hampered
agricultural productivity worldwide. Both stresses can induce several morphological …

Organic acids could improve the food flavor, maintain the nutritional value, and extend the
shelf life of food. This review summarizes the detection methods and concentrations of …

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …

Mutations in metabolic enzymes, including isocitrate dehydrogenase 1 (IDH1) and IDH2, in
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …

Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron
donor in all organisms. It provides the reducing power that drives numerous anabolic …

Nonalcoholic fatty liver disease (NAFLD) affects about 30% of the general population in the
United States and includes a spectrum of disease that includes simple steatosis, non …

Reactive oxygen species (ROS), natural by-products of aerobic respiration, are important
cell signaling molecules, which left unchecked can severely impair cellular functions and …

Dysregulation of metabolism is a common phenomenon in cancer cells. The NADP+-
dependent isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) function at a crossroads of …

Caloric restriction, fasting, and exercise have long been recognized for their neuroprotective
and lifespan-extending properties; however, the underlying mechanisms of these …

Oncogenic mutations in two isocitrate dehydrogenase (IDH)-encoding genes (IDH1 and
IDH2) have been identified in acute myelogenous leukemia, low-grade glioma, and …