Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of
glutamate is of paramount importance for normal brain function and relies on an intricate …

Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …

Huntington disease (HD) is a monogenic disease that results in a combination of motor,
psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion …

In the mammalian brain, glutamate is regarded to be the primary excitatory neurotransmitter
due to its widespread distribution and wide range of metabolic functions. Glutamate plays …

The term type III diabetes (T3DM) has been proposed for Alzheimer's disease (AD) due to
the shared molecular and cellular features between type 2 diabetes (T2DM) and insulin …

Glutamate (GLU) is a primary excitatory neurotransmitter, and its dysregulation is associated
with several neurodegenerative disorders. A major challenge in GLU estimation is the …

The etiopathogenesis of late-onset Alzheimer's disease (AD) is increasingly recognized as
the result of the combination of the aging process, toxic proteins, brain dysmetabolism, and …

Most research on glutamate spillover focuses on the deleterious consequences of
postsynaptic glutamate receptor overactivation. However, two decades ago, it was noted that …