Objective. The current study aimed to explore the efficacy of Zero profile intervertebral fusion
system (Zero‐P) and traditional anterior plate cage system (PC) in the treatment of cervical …

RSK2 is a serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90 RSK;
RSKs) family, which regulates cell proliferation and transformation induced by tumor …

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers and is
highly resistant to current treatments. ESCC harbors a subpopulation of cells exhibiting …

Resolution to chemoresistance is a major challenge in patients with advanced-stage
malignancies. Thus, identification of action points and elucidation of molecular mechanisms …

Rheumatoid arthritis (RA) is a systemic inflammatory disease that mainly affects the synovial
joints. Although involvement of the fibroblast growth factor (FGF) signaling pathway has …

Although GSK3β has been reported to have contrasting effects on the progression of
different tumors, it's possible functions in esophageal squamous cell carcinoma (ESCC) and …

Background Magnolin is a natural compound abundantly found in Magnolia flos, which has
been traditionally used in oriental medicine to treat headaches, nasal congestion and anti …

Background Growth factors induce a characteristically short-lived Ras activation in cells
emerging from quiescence. Extensive work has shown that transient as opposed to …

Ribosomal S6 kinase 2 (RSK2), regulated by Ras/Raf/MEKs/ERKs, transmits upstream
activation signals to downstream substrates including kinases and transcription and …

Cancer cells often exhibit resistance to apoptotic cell death, but they may be vulnerable to
other types of cell death. Elucidating additional mechanisms that govern cancer cell death is …