[HTML][HTML] Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity

S Bliddal, CH Nielsen, U Feldt-Rasmussen - F1000Research, 2017 - ncbi.nlm.nih.gov
Autoimmune thyroid disease (AITD) is often observed together with other autoimmune
diseases. The coexistence of two or more autoimmune diseases in the same patient is …

MAP4K family kinases and DUSP family phosphatases in T-cell signaling and systemic lupus erythematosus

HC Chuang, TH Tan - Cells, 2019 - mdpi.com
T cells play a critical role in the pathogenesis of systemic lupus erythematosus (SLE), which
is a severe autoimmune disease. In the past 60 years, only one new therapeutic agent with …

A systematic review of extreme phenotype strategies to search for rare variants in genetic studies of complex disorders

S Amanat, T Requena, JA Lopez-Escamez - Genes, 2020 - mdpi.com
Exome sequencing has been commonly used to characterize rare diseases by selecting
multiplex families or singletons with an extreme phenotype (EP) and searching for rare …

A genome-wide association study finds genetic associations with broadly-defined headache in UK Biobank (N= 223,773)

W Meng, MJ Adams, HL Hebert, IJ Deary… - …, 2018 - thelancet.com
Background Headache is the most common neurological symptom and a leading cause of
years lived with disability. We sought to identify the genetic variants associated with a …

MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics

S Rajan, JR Terman, E Reisler - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Actin and its dynamic structural remodelings are involved in multiple cellular functions,
including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle …

Polyautoimmunity in Sjögren syndrome

JM Anaya, A Rojas-Villarraga… - Rheumatic …, 2016 - rheumatic.theclinics.com
Autoimmune diseases (ADs) are chronic conditions initiated by the loss of immunologic
tolerance to self-antigens due to the interaction of hereditary (ie, genetics and epigenetics) …

[HTML][HTML] Genetics of non-syndromic childhood obesity and the use of high-throughput DNA sequencing technologies

ACP da Fonseca, C Mastronardi, A Johar… - Journal of Diabetes and …, 2017 - Elsevier
Background Childhood obesity is a serious public health problem associated with the
development of several chronic diseases, such as type 2 diabetes mellitus, dyslipidemia …

Cytokine and autoantibody clusters interaction in systemic lupus erythematosus

Y Pacheco, J Barahona-Correa, DM Monsalve… - Journal of Translational …, 2017 - Springer
Background Evidence supports the existence of different subphenotypes in systemic lupus
erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a …

Transcriptional classification and functional characterization of human airway macrophage and dendritic cell subsets

VI Patel, JL Booth, ES Duggan, S Cate… - The Journal of …, 2017 - journals.aai.org
The respiratory system is a complex network of many cell types, including subsets of
macrophages and dendritic cells that work together to maintain steady-state respiration …

Hybrid FES–robotic gait rehabilitation technologies: a review on mechanical design, actuation, and control strategies

F Anaya, P Thangavel, H Yu - International journal of intelligent robotics …, 2018 - Springer
Gait disorders in neurologically disabled people can be treated by various techniques
available today which include passive orthoses, functional electrical stimulation (FES) and …