Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

How long organisms live is not entirely written in their genes. Recent findings reveal that
epigenetic factors that regulate histone methylation, a type of chromatin modification, can …

Early host responses toward pathogens are essential for defense against infection. In
Caenorhabditis elegans, the transcription factor, SKN-1, regulates cellular defenses during …

DNA damage causes cancer, impairs development and accelerates aging. Transcription-
blocking lesions and transcription-coupled repair defects lead to developmental failure and …

Genome-wide analyses in Caenorhabditis elegans show that post-translational
modifications (PTMs) of histones are evolutionary conserved and distributed along …

Throughout their journey to forming new individuals, germline stem cells must remain
totipotent, particularly by maintaining a specific chromatin structure. However, the place …

Quiescence, an actively-maintained reversible state of cell cycle arrest, is not well
understood. PTEN is one of the most frequently lost tumor suppressors in human cancers …

Methylation of histone 3 lysine 4 (H3K4) is largely associated with promoters and enhancers
of actively transcribed genes and is finely regulated during development by the action of …

ABSTRACT Poly (U) polymerases (PUPs) catalyze 3′ uridylation of mRNAs and small
RNAs, a modification often correlating with decreased RNA stability. We have investigated …

In Caenorhabditis elegans, germline cells remain transcriptionally silenced during
embryogenesis. The transcriptional silencing is achieved by two different mechanisms: One …