We define a new concept of 'active milieu'that unifies all components of nervous tissue
(neuronal and glial compartments, extracellular space, extracellular matrix, and vasculature) …

Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Cell-death and-survival decisions are critically controlled by intracellular Ca 2+ homeostasis
and dynamics at the level of the endoplasmic reticulum (ER). Inositol 1, 4, 5-trisphosphate …

Abstract IP 3 receptor (IP 3 R) was found to release Ca 2+ from non-mitochondrial store but
the exact localization and the mode of action of IP 3 remained a mystery. IP 3 R was …

Inositol trisphosphate receptors (IP3Rs) are ubiquitous Ca2+-permeable channels that
mediate release of Ca2+ from the endoplasmic reticulum, thereby regulating numerous …

Ca 2+ influx through an astrocyte plasma membrane is mediated by ionotropic receptors
and Ca 2+ channels according the electrochemical gradient. These conductances allow …

Cells sense and respond to extracellular mechanical stress through mechanotransduction
receptors and ion channels, which regulate cellular behaviors such as cell proliferation and …

Astrocytes express a complex repertoire of intracellular Ca2+ transients (events) that
represent a major form of signaling within individual cells and in astrocytic syncytium. These …

The complexity of the signaling network that underlies astrocyte-synapse interactions may
seem discouraging when tackled from a theoretical perspective. Computational modeling is …

The study of the astrocytic contribution to brain functions has been growing in popularity in
the neuroscience field. In the last years, and especially since the demonstration of the …