Acute myeloid leukemia (AML) is a polyclonal and heterogeneous hematological
malignancy. Relapse and refractory after induction chemotherapy are still challenges for …

Retinoic acid (RA), the derivative of vitamin A/retinol, is a signaling molecule with important
implications in health and disease. It is a well-known developmental morphogen that …

Objective: To explore the role and mechanism of the Kelch sample related protein-1-nuclear
factor erythroid-2 related factor 2/antioxidant response element (Keap1-Nrf2/ARE) signaling …

Pancreatic cancer is one of the leading causes of cancer deaths, with pancreatic ductal
adenocarcinoma (PDAC) being the most common subtype. Advanced stage diagnosis of …

Background Myeloid leukemia is associated with reduced serum zinc and increased
intracellular zinc. Our previous studies found that zinc depletion by TPEN induced apoptosis …

Abstract Anoikis-Related Genes (ARGs) lead to the organism manifesting resistance to
anoikis and are associated with unfavorable prognostic outcomes across various …

Cytoglobin (CYGB) is a member of the oxygen-binding globin superfamily. In this study we
generated stable CYGB overexpressing A375 melanoma cells and performed RNA …

MYC plays a central role in tumorigenesis by orchestrating cell proliferation, growth and
survival, among other transformation mechanisms. In particular, MYC has often been …

VDX-111 (also identified as AMPI-109) is a vitamin D derivative which has shown anticancer
activity. To further assess the function of this compound against multiple cancer types, we …

The vitamin A metabolite all-trans retinoic acid (ATRA; tretinoin) has anticancer potential.
However, lack of clinical success has prevented its approval for solid tumours. Herein, we …