Circadian rhythms and cancers: the intrinsic links and therapeutic potentials
The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …
Training the circadian clock, clocking the drugs, and drugging the clock to prevent, manage, and treat chronic diseases
Daily rhythms in behavior, physiology, and metabolism are an integral part of homeostasis.
These rhythms emerge from interactions between endogenous circadian clocks and …
These rhythms emerge from interactions between endogenous circadian clocks and …
The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome
Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …
[HTML][HTML] Timing to perfection: the biology of central and peripheral circadian clocks
U Albrecht - Neuron, 2012 - cell.com
The mammalian circadian system, which is comprised of multiple cellular clocks located in
the organs and tissues, orchestrates their regulation in a hierarchical manner throughout the …
the organs and tissues, orchestrates their regulation in a hierarchical manner throughout the …
REV-ERB and ROR nuclear receptors as drug targets
DJ Kojetin, TP Burris - Nature reviews Drug discovery, 2014 - nature.com
The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …
International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …
gene network programs involved in a wide range of physiologic processes. This review will …
A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis
Retinoic acid–related orphan receptor α (RORα) is considered a key regulator of
polarization in liver macrophages that is closely related to nonalcoholic steatohepatitis …
polarization in liver macrophages that is closely related to nonalcoholic steatohepatitis …
ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by poor
response to standard therapies and therefore unfavorable clinical outcomes. Better …
response to standard therapies and therefore unfavorable clinical outcomes. Better …
Clocking cancer: the circadian clock as a target in cancer therapy
Disruption of the cellular pathway modulating endogenous 24-h rhythms, referred to as “the
circadian clock”, has been recently proven to be associated with cancer risk, development …
circadian clock”, has been recently proven to be associated with cancer risk, development …
Time to target the circadian clock for drug discovery
ES Rasmussen, JS Takahashi, CB Green - Trends in biochemical sciences, 2022 - cell.com
The circadian clock is an intracellular timekeeping device that drives daily rhythms in diverse
and extensive processes throughout the body. The clock mechanism comprises a core …
and extensive processes throughout the body. The clock mechanism comprises a core …