Dengue is the leading mosquito-borne viral illness infecting humans. Owing to the
circulation of multiple serotypes, global expansion of the disease and recent gains in …

Dengue is a mosquito-borne viral disease (arboviral) caused by the Dengue virus. It is one
of the prominent public health problems in tropical and subtropical regions with no effective …

To combat neglected diseases, the Novartis Institute of Tropical Diseases (NITD) was
founded in 2002 through private–public funding from Novartis and the Singapore Economic …

Transmission from an infected mosquito to a host is an essential process in the life cycle of
mosquito-borne flaviviruses. Numerous studies have demonstrated that mosquito saliva …

Zika virus (ZIKV) was once considered an obscure member of the large and diverse family of
mosquito-borne flaviviruses, and human infections with ZIKV were thought to be sporadic …

Approximately 100–400 million people from more than 100 countries in the tropical and
subtropical world are affected by dengue infections. Recent scientific breakthroughs have …

Dengue virus (DENV) infection causes a characteristic pathology in humans involving
dysregulation of the vascular system. In some patients with dengue hemorrhagic fever …

As obligate parasites, viruses strictly depend on host cell translation for the production of
new progeny, yet infected cells also synthesize antiviral proteins to limit virus infection …

Highlights•Biomarkers of severe dengue can potentially improve clinical dengue outcomes
and alleviate the healthcare burden in dengue-endemic settings.•Risk factors for severe …

Insect-borne flaviviruses produce a 300–500–base long noncoding RNA, termed
subgenomic flavivirus RNA (sfRNA), by stalling the cellular 5′–3′-exoribonuclease 1 …