Macrophages in tissue repair, regeneration, and fibrosis
TA Wynn, KM Vannella - Immunity, 2016 - cell.com
Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …
The macrophage-osteoclast axis in osteoimmunity and osteo-related diseases
Y Yao, X Cai, F Ren, Y Ye, F Wang, C Zheng… - Frontiers in …, 2021 - frontiersin.org
Osteoimmunity is involved in regulating the balance of bone remodeling and resorption, and
is essential for maintaining normal bone morphology. The interaction between immune cells …
is essential for maintaining normal bone morphology. The interaction between immune cells …
Immunometabolism governs dendritic cell and macrophage function
LAJ O'Neill, EJ Pearce - Journal of Experimental Medicine, 2016 - rupress.org
Recent studies on intracellular metabolism in dendritic cells (DCs) and macrophages
provide new insights on the functioning of these critical controllers of innate and adaptive …
provide new insights on the functioning of these critical controllers of innate and adaptive …
Computational reconstruction of the signalling networks surrounding implanted biomaterials from single-cell transcriptomics
The understanding of the foreign-body responses to implanted biomaterials would benefit
from the reconstruction of intracellular and intercellular signalling networks in the …
from the reconstruction of intracellular and intercellular signalling networks in the …
The long noncoding RNA MALAT 1 regulates the lipopolysaccharide‐induced inflammatory response through its interaction with NF‐κB
G Zhao, Z Su, D Song, Y Mao, X Mao - FEBS letters, 2016 - Wiley Online Library
MALAT 1 is a conserved long noncoding RNA whose expression correlates with many
human cancers. However, its significance in immunity remains largely unknown. Here, we …
human cancers. However, its significance in immunity remains largely unknown. Here, we …
[HTML][HTML] β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic …
H Li, Q Liu, C Zhu, X Sun, C Sun, C Yu, P Li, X Deng… - Redox Biology, 2023 - Elsevier
Sepsis-associated encephalopathy (SAE) is one of the common serious complications in
sepsis, and the pathogenesis of SAE remains unclear. Sirtuin 1 (SIRT1) has been reported …
sepsis, and the pathogenesis of SAE remains unclear. Sirtuin 1 (SIRT1) has been reported …
A20/tumor necrosis factor α-induced protein 3 in immune cells controls development of autoinflammation and autoimmunity: lessons from mouse models
T Das, Z Chen, RW Hendriks, M Kool - Frontiers in immunology, 2018 - frontiersin.org
Immune cell activation is a stringently regulated process, as exaggerated innate and
adaptive immune responses can lead to autoinflammatory and autoimmune diseases …
adaptive immune responses can lead to autoinflammatory and autoimmune diseases …
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions
ABSTRACT SIRT3 (sirtuin 3), a mitochondrial protein deacetylase, maintains respiratory
function, but its role in the regulation of innate immune defense is largely unknown. Herein …
function, but its role in the regulation of innate immune defense is largely unknown. Herein …
A20 at the crossroads of cell death, inflammation, and autoimmunity
A Martens, G van Loo - Cold Spring Harbor perspectives …, 2020 - cshperspectives.cshlp.org
A20 is a potent anti-inflammatory protein, acting by inhibiting nuclear factor κB (NF-κB)
signaling and inflammatory gene expression and/or by preventing cell death. Mutations in …
signaling and inflammatory gene expression and/or by preventing cell death. Mutations in …
PPAR-α activation mediates innate host defense through induction of TFEB and lipid catabolism
The role of peroxisome proliferator–activated receptor α (PPAR-α) in innate host defense is
largely unknown. In this study, we show that PPAR-α is essential for antimycobacterial …
largely unknown. In this study, we show that PPAR-α is essential for antimycobacterial …