Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …

Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

An increasing recognition that brain and body are dynamically coupled has enriched our
scientific understanding of mental health conditions. Peripheral signals interact centrally to …

We examined whether inflammation is uniformly associated with all depressive and anxiety
symptoms, and whether these associations are potentially causal. Data was from 147,478 …

Introduction Meta-analyses implicate immune dysfunction in depression confirming
increased levels of circulating immune proteins (eg, cytokines) in depression cases …

Psychosocial stress has profound effects on the body, including the immune system and the
brain,. Although a large number of pre-clinical and clinical studies have linked peripheral …

Notwithstanding advances in understanding the pathophysiology of major depressive
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …

Background Depression is a recurrent and devastating mental disease that is highly
prevalent worldwide. Prolonged exposure to stressful events or a stressful environment is …

Background Research on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio
(PLR), and monocyte-to-lymphocyte ratio (MLR) in depression is still emerging and has …

Multiple psychiatric disorders have been associated with abnormalities in both the innate
and adaptive immune systems. The role of these abnormalities in pathogenesis, and …