Myelin facilitates the fast transmission of nerve impulses and provides metabolic support to
axons. Differentiation of oligodendrocyte progenitor cells (OPCs) and Schwann cell (SC) …

The epidermal growth factor receptor (EGFR) belongs to the ErbB-family of receptor tyrosine
kinases that are of importance in oncology. During the last years, substantial evidence …

Inflammation and immune responses are intricately intertwined processes crucial for
maintaining homeostasis and combating against pathogens. These processes involve …

Abstract Sphingosine-1-Phosphate (S1P) is a potent signaling lipid. The effects of S1P are
mediated by the five S1P receptors (S1PR). In the endothelium S1PR1 is the predominant …

Abstract Sphingosine kinase 1 (SK1) converts the pro‐death lipid sphingosine to the pro‐
survival sphingosine‐1‐phosphate (S1P) and is upregulated in several cancers. DNA …

Sphingosine kinases (SphKs) catalyze the conversion of the sphingosine to the
promitogenic/migratory product, sphingosine-1-phosphate (S1P). SphK/S1P pathway has …

Sphingolipids (SLs), which have structural and biological responsibilities in the human
epidermis, are importantly involved in the maintenance of the skin barrier and regulate …

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. A sequence
of pathological processes occurred when there is TBI. Previous studies showed that …

We previously demonstrated that activation of sphingosine kinase 1 (SphK1)-sphingosine 1-
phosphate (S1P) signaling pathway by high glucose (HG) plays a pivotal role in increasing …

Traumatic brain injury (TBI) provokes secondary pathological mechanisms, including
ischemic and inflammatory processes. The new research in sphingosine 1-phosphate (S1P) …