Protein-protein interactions (PPIs) are well-established as a class of promising drug targets
for their implications in a wide range of biological processes. However, drug development …

Hsp90 is one of the most important chaperones involved in regulating the maturation of
more than 300 client proteins, many of which are closely associated with refractory diseases …

Celastrol (CEL), an active compound isolated from the root of Tripterygium wilfordii, exhibits
broad anticancer activities. However, its poor stability, narrow therapeutic window and …

Parthanatos-associated apoptosis-inducing factor (AIF) nuclease (PAAN), also known as
macrophage migration inhibitor factor (MIF), is a member of the PD-D/E (X) K nucleases that …

Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing
protein structures, facilitating the repair or degradation of damaged proteins, and …

Inefficient tumour treatment approaches often cause fatal tumour metastases. Here, we
report a biomimetic multifunctional nanoplatform explicitly engineered with a Co-based …

Abstract The 90-kiloDalton (kD) heat shock protein (Hsp90) is a ubiquitous, ATP-dependent
molecular chaperone whose primary function is to ensure the proper folding of several …

In the past decade, bio-nanoparticles inspired by nature with advantageous properties have
attracted extensive interest for accurate diagnosis and effective treatment. Extracellular …

Abstract Heat shock protein 90 (HSP90) is an indispensable molecular chaperone that
facilitates the maturation of numerous oncoproteins in cancer cells, including protein …

Pulmonary arterial hypertension (PAH) is a severe pulmonary vascular disorder marked by
vascular remodeling, which is linked to the malignant phenotypes of pulmonary vascular …