Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

High levels of lactate are positively associated with the prognosis and mortality in patients
with heart attack. Endothelial-to-mesenchymal transition (EndoMT) plays an important role in …

The metabolic rewiring of cardiomyocytes is a widely accepted hallmark of heart failure (HF).
These metabolic changes include a decrease in mitochondrial pyruvate oxidation and an …

The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac
structure and contraction. However, the mechanism regulating this interaction in normal and …

Aims Metabolic switching during heart development contributes to postnatal cardiomyocyte
(CM) cell cycle exit and loss of regenerative capacity in the mammalian heart. Metabolic …

Background: The integrated stress response (ISR) is an evolutionarily conserved process to
cope with intracellular and extracellular disturbances. Myocardial infarction is a leading …

Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

Background: Metabolic remodeling precedes most alterations during cardiac hypertrophic
growth under hemodynamic stress. The elevation of glucose utilization has been recognized …

Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of
glioblastoma. By screening a cluster of metabolic small-molecule compounds, we show that …