Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

New opportunities and old challenges in the clinical translation of nanotheranostics

PJ Gawne, M Ferreira, M Papaluca, J Grimm… - Nature reviews …, 2023 - nature.com
Nanoparticle-based systems imbued with both diagnostic and therapeutic functions, known
as nanotheranostics, have enabled remarkable progress in guiding focal therapy, inducing …

Thermal immuno-nanomedicine in cancer

Z Yang, D Gao, J Zhao, G Yang, M Guo… - Nature Reviews …, 2023 - nature.com
Immunotherapy has revolutionized the treatment of patients with cancer. However,
promoting antitumour immunity in patients with tumours that are resistant to these therapies …

The use of alternative strategies for enhanced nanoparticle delivery to solid tumors

M Izci, C Maksoudian, BB Manshian… - Chemical …, 2021 - ACS Publications
Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …

[HTML][HTML] Plant exosome-like nanovesicles: emerging therapeutics and drug delivery nanoplatforms

HA Dad, TW Gu, AQ Zhu, LQ Huang, LH Peng - Molecular Therapy, 2021 - cell.com
Plant exosome-like nanovesicles, being innately replete with bioactive lipids, proteins, RNA,
and other pharmacologically active molecules, offer unique morphological and …

Strategies to improve the EPR effect: A mechanistic perspective and clinical translation

M Ikeda-Imafuku, LLW Wang, D Rodrigues… - Journal of Controlled …, 2022 - Elsevier
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

Tumor targeting via EPR: Strategies to enhance patient responses

SK Golombek, JN May, B Theek, L Appold… - Advanced drug delivery …, 2018 - Elsevier
The tumor accumulation of nanomedicines relies on the enhanced permeability and
retention (EPR) effect. In the last 5–10 years, it has been increasingly recognized that there …

Engineered nanomedicines with enhanced tumor penetration

J Ding, J Chen, L Gao, Z Jiang, Y Zhang, M Li, Q Xiao… - Nano Today, 2019 - Elsevier
Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …

Ultrasound‐activated sensitizers and applications

X Lin, J Song, X Chen, H Yang - … Chemie International Edition, 2020 - Wiley Online Library
Modalities for photo‐triggered anticancer therapy are usually limited by their low penetrative
depth. Sonotheranostics especially sonodynamic therapy (SDT), which is different from …

Nanodrug delivery: is the enhanced permeability and retention effect sufficient for curing cancer?

Y Nakamura, A Mochida, PL Choyke… - Bioconjugate …, 2016 - ACS Publications
Nanotechnology offers several attractive design features that have prompted its exploration
for cancer diagnosis and treatment. Nanosized drugs have a large loading capacity, the …